SCHEMBL8642019

SCHEMBL8642019

CCOC(=O)N[C@H]1CCc2ccccc2[C@@H]1Cl

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.49
DRD2 P14416 1/20 0.43
HTT P42858 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
ALDH1A1 P00352 3/20 0.41
TAS1R3 Q7RTX0 2/20 0.39
TAS1R1 Q7RTX1 2/20 0.39
TAS1R2 Q8TE23 2/20 0.39
MTNR1A P48039 3/20 0.39
MTNR1B P49286 3/20 0.39
MAPT P10636 1/20 0.39
XBP1 P17861 1/20 0.39
NTRK1 P04629 2/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8642023 1.00 ATM (0.49) ATMDRD2HTTSMN1; SMN2KMT2A
SCHEMBL8642025 1.00 ATM (0.49) ATMDRD2HTTSMN1; SMN2KMT2A
SCHEMBL8635110 0.87 ATM (0.60) ATMDRD2SMN1; SMN2KMT2AMEN1
SCHEMBL7375674 0.87 ATM (0.60) ATMDRD2SMN1; SMN2KMT2AMEN1
SCHEMBL10919227 0.82 TAS1R3 (0.45) HTTKMT2AMEN1ALDH1A1TAS1R3
SCHEMBL10919224 0.82 TAS1R3 (0.45) HTTKMT2AMEN1ALDH1A1TAS1R3
SCHEMBL61382 0.76 ALDH1A1 (0.63) HTTKMT2AMEN1ALDH1A1TAS1R3
SCHEMBL61381 0.76 ALDH1A1 (0.63) HTTKMT2AMEN1ALDH1A1TAS1R3
SCHEMBL10854343 0.76 ATM (0.42) ATMDRD2HTTSMN1; SMN2KMT2A
SCHEMBL10854332 0.76 ATM (0.42) ATMDRD2HTTSMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5773463-A DECALCIFICATION OF BRAIN DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-06-30 US disclosed
US-4638066-A ANTIDEPRESSANTS BEECHAM GROUP P.L.C. (GB) 1987-01-20 US disclosed
EP-0088575-B1 PENTACYCLIC COMPOUNDS BEECHAM GROUP PLC (GB) 1986-12-30 EP disclosed
US-4585588-A ANTIDEPRESSANTS BEECHAM GROUP P.L.C. (GB) 1986-04-29 US disclosed
US-4504480-A DIAZABENZOCYCLOHEPTAFLUORENE DERIVATRIVES, ANTIDEPRESSANTS BEECHAM GROUP P.L.C. (GB) 1985-03-12 US disclosed