Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758984 | 0.85 | POLB (0.47) | POLBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8758970 | 0.84 | POLB (0.46) | POLBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL9063248 | 0.79 | PTPN1 (0.58) | POLBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL27833941 | 0.79 | CYP3A4 (0.41) | POLBKDM4ENPC1ALDH1A1 | |
| SCHEMBL2628188 | 0.78 | POLB (0.59) | POLBSMN1; SMN2KDM4ECYP1A2MAPT | |
| SCHEMBL8759406 | 0.76 | KDM4E (0.50) | POLBSMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8634781 | 0.76 | SLC6A4 (0.47) | — | |
| SCHEMBL8634785 | 0.76 | SLC6A4 (0.47) | — | |
| SCHEMBL8634784 | 0.76 | SLC6A4 (0.47) | — | |
| SCHEMBL8635512 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717746-B1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-15 | — | — | EP | disclosed |
| EP-0717746-A1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007284-A1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-03-16 | — | — | WO | disclosed |