Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638521 | 0.82 | GAA (0.44) | GAASMN1; SMN2AKR1C3ALDH1A1MAPT | |
| SCHEMBL8633138 | 0.79 | PREP (0.53) | GAAALDH1A1 | |
| SCHEMBL8633642 | 0.77 | HCRTR1 (0.53) | GAASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL8633638 | 0.77 | HCRTR1 (0.53) | GAASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL23884759 | 0.68 | HSD17B10 (0.41) | SMN1; SMN2ALDH1A1HCRTR1HCRTR2NPSR1 | |
| SCHEMBL700595 | 0.67 | AKR1C3 (0.85) | GAAAKR1C3ALDH1A1MAPTPKM | |
| SCHEMBL29447165 | 0.67 | AKR1C3 (0.85) | GAAAKR1C3ALDH1A1MAPTPKM | |
| SCHEMBL3318857 | 0.67 | HCRTR1 (0.40) | ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL23884841 | 0.67 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL23884840 | 0.67 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |