Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | ACP1 | P24666 | 4/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641732 | 0.89 | PTPN1 (0.51) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8638111 | 0.83 | MEN1 (0.51) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8635613 | 0.80 | MEN1 (0.54) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8636932 | 0.79 | ESR1 (0.51) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8636723 | 0.77 | MEN1 (0.56) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8637350 | 0.72 | ALDH1A1 (0.53) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL9669237 | 0.71 | MEN1 (0.68) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL28159082 | 0.69 | MEN1 (0.48) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8637238 | 0.69 | XDH (0.49) | MEN1KMT2AMAPTKDM4ECYP3A4 | |
| SCHEMBL8638845 | 0.69 | HSD17B3 (0.56) | MEN1KMT2AMAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516257-B1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AG (DE) | 1998-08-05 | — | — | EP | disclosed |
| US-5470854-A | Antiestrogens | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | disclosed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | disclosed |