Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10829174 | 0.84 | LTA4H (0.68) | LTA4HMEN1KMT2ARECQLKDM4E | |
| SCHEMBL10423138 | 0.84 | HPGD (0.64) | TAAR1MEN1KMT2AHPGDRECQL | |
| SCHEMBL24976893 | 0.83 | KMT2A (0.54) | TAAR1MEN1KMT2AHPGDRECQL | |
| SCHEMBL8935389 | 0.80 | LMNA (0.67) | TAAR1RECQLLMNAALDH1A1 | |
| SCHEMBL8639333 | 0.79 | LTA4H (0.64) | LTA4H | |
| SCHEMBL19185423 | 0.79 | HPGD (0.62) | TAAR1MEN1KMT2AHPGDRECQL | |
| SCHEMBL7134887 | 0.78 | LTA4H (0.80) | LTA4HMEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7757373 | 0.78 | RECQL (0.71) | TAAR1MEN1KMT2AHPGDRECQL | |
| SCHEMBL8639936 | 0.78 | LTA4H (0.62) | LTA4H | |
| SCHEMBL7136224 | 0.78 | LTA4H (1.00) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |