Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 11/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639322 | 0.96 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8641254 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8641864 | 0.88 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8644228 | 0.88 | LTA4H (0.52) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8640783 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL17842262 | 0.86 | RAB9A (0.75) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8773761 | 0.86 | MEN1 (0.54) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8640087 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8641245 | 0.83 | NPC1 (0.60) | SMN1; SMN2NPC1RAB9APKMEPHX2 | |
| SCHEMBL8637335 | 0.81 | LTA4H (0.56) | ALDH1A1MEN1KMT2AKDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |