Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640059 | 0.86 | LTA4H (0.50) | LTA4HKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL19469277 | 0.83 | PKM (0.51) | LTA4HKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7326383 | 0.83 | LTA4H (0.49) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8639933 | 0.81 | RAB9A (0.50) | LTA4HALDH1A1KMT2AITGB3ITGA2B | |
| SCHEMBL8635989 | 0.81 | SMN1; SMN2 (0.57) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8639322 | 0.80 | SMN1; SMN2 (0.62) | LTA4HHRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8637144 | 0.79 | LTA4H (0.47) | LTA4HHRH1MEN1ALDH1A1KMT2A | |
| SCHEMBL27694957 | 0.79 | AKR1B10 (0.47) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8642313 | 0.78 | LTA4H (0.47) | LTA4HMEN1ALDH1A1KMT2AITGB3 | |
| SCHEMBL8637391 | 0.78 | LTA4H (0.49) | LTA4HHRH1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |