Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004261 | 0.77 | HDAC4 (0.42) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18611832 | 0.72 | HDAC4 (0.41) | HDAC4SLC6A4SLC6A3SLC6A2KDM1A | |
| SCHEMBL8766211 | 0.65 | HSD11B1 (0.53) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10356662 | 0.65 | HDAC4 (0.41) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL527776 | 0.65 | HDAC4 (0.45) | HDAC4SLC6A4SLC6A3SLC6A2PDE7A | |
| SCHEMBL10601663 | 0.65 | HDAC4 (0.38) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2589110 | 0.63 | SLC6A2 (0.47) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL10336534 | 0.62 | CYP1A2 (0.36) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17982792 | 0.62 | HDAC4 (0.47) | HDAC4 | |
| SCHEMBL11840369 | 0.62 | OPRM1 (0.54) | HDAC4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601191-B1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0601191-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1994-06-15 | — | — | EP | disclosed |