Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635649 | 0.84 | PREP (0.45) | LMNAHCRTR1HCRTR2POLB | |
| SCHEMBL8639314 | 0.82 | LMNA (0.46) | LMNASPHK2HCRTR1HCRTR2RIPK1 | |
| SCHEMBL17600702 | 0.80 | L3MBTL1 (0.53) | ABL1RIN1SPHK2CYP3A4RIPK1 | |
| SCHEMBL17600703 | 0.80 | L3MBTL1 (0.53) | ABL1RIN1SPHK2CYP3A4RIPK1 | |
| SCHEMBL6370221 | 0.77 | CHRNA7 (0.43) | LMNAHCRTR2 | |
| SCHEMBL31245524 | 0.74 | HCRTR2 (0.49) | ABL1RIN1LMNAHCRTR1HCRTR2 | |
| SCHEMBL21958017 | 0.74 | HCRTR2 (0.49) | ABL1RIN1LMNAHCRTR1HCRTR2 | |
| SCHEMBL21958015 | 0.74 | HCRTR2 (0.49) | ABL1RIN1LMNAHCRTR1HCRTR2 | |
| SCHEMBL4480837 | 0.73 | TP53 (0.60) | LMNASPHK2HCRTR1HCRTR2POLB | |
| SCHEMBL4480840 | 0.73 | TP53 (0.60) | LMNASPHK2HCRTR1HCRTR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |