Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636150 | 0.84 | ABL1 (0.43) | HCRTR2POLBLMNAHCRTR1 | |
| SCHEMBL8634326 | 0.82 | PREP (0.51) | PREPALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL25796211 | 0.80 | L3MBTL1 (0.53) | PREPALDH1A1KMT2AMEN1 | |
| SCHEMBL6370221 | 0.77 | CHRNA7 (0.43) | HCRTR2KMT2AMEN1LMNA | |
| SCHEMBL13272425 | 0.76 | PREP (0.47) | PREPHCRTR2HSD11B1ALDH1A1KMT2A | |
| SCHEMBL8633260 | 0.71 | PREP (0.54) | PREPHCRTR2ALDH1A1HCRTR1 | |
| SCHEMBL5173202 | 0.70 | PREP (0.51) | PREPALDH1A1POLB | |
| SCHEMBL11447174 | 0.70 | PREP (0.51) | PREPALDH1A1POLB | |
| SCHEMBL7284818 | 0.70 | PREP (0.51) | PREPALDH1A1POLB | |
| SCHEMBL8632678 | 0.69 | TSHR (0.54) | PREPALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |