Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636588 | 0.81 | FDPS (0.56) | FDPSSMN1; SMN2PTPRACYP1A2ALDH1A1 | |
| SCHEMBL8629603 | 0.77 | FDPS (0.51) | FDPSSMN1; SMN2PTPRACYP1A2ALDH1A1 | |
| Lithium Ion SCHEMBL31084604 | 0.74 | RAB9A (0.53) | FDPSSMN1; SMN2PTPRACYP1A2ALDH1A1 | |
| Lithium Ion SCHEMBL988401 | 0.74 | RAB9A (0.53) | FDPSSMN1; SMN2PTPRACYP1A2ALDH1A1 | |
| Lithium Ion SCHEMBL28463950 | 0.73 | CYP1A2 (0.56) | SMN1; SMN2PTPRACYP1A2ALDH1A1TSHR | |
| SCHEMBL6638562 | 0.73 | FDPS (0.54) | FDPSSMN1; SMN2PTPRACYP1A2ALDH1A1 | |
| Lithium Ion SCHEMBL8631509 | 0.72 | CYP1A2 (0.48) | CYP1A2ALDH1A1KDM4E | |
| Lithium Ion SCHEMBL8632583 | 0.72 | MMP8 (0.49) | FDPSSMN1; SMN2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL5052828 | 0.72 | FDPS (0.58) | FDPSSMN1; SMN2PTPRAALDH1A1HRH1 | |
| SCHEMBL3896340 | 0.72 | FDPS (0.58) | FDPSSMN1; SMN2CYP1A2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773465-A | Tartronic acids, their acetalic ethers and o-esters | DOMPE FARMACEUTICI S.P.A. (IT) | 1998-06-30 | — | — | US | disclosed |
| US-5656656-A | Tartronic acids, their acetalic ethers and O-esters | DOMPE FARMACEUTICI S.P.A. (IT) | 1997-08-12 | — | — | US | disclosed |
| EP-0667850-B1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE FARMACEUTICI SPA (IT) | 1997-05-28 | — | — | EP | disclosed |
| EP-0667850-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS. | DOMPE FARMACEUTICI SPA (IT) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010127-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE' FARMACEUTICI S.P.A. (IT) | 1994-05-11 | — | — | WO | disclosed |