Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636651 | 1.00 | PREP (0.69) | PREPHRH3KMT2AHCRTR1HCRTR2 | |
| SCHEMBL8635557 | 0.83 | PREP (0.69) | PREPHRH3KMT2ALMNAGAA | |
| SCHEMBL8633138 | 0.80 | PREP (0.53) | PREPKMT2ALMNAGAAHPGD | |
| SCHEMBL9538915 | 0.80 | PREP (0.64) | PREPHRH3KMT2AAPEX1POLB | |
| SCHEMBL8635668 | 0.80 | PREP (0.64) | PREPHRH3KMT2AAPEX1POLB | |
| SCHEMBL8633642 | 0.79 | HCRTR1 (0.53) | KMT2AHCRTR1HCRTR2SPHK2LMNA | |
| SCHEMBL8633638 | 0.79 | HCRTR1 (0.53) | KMT2AHCRTR1HCRTR2SPHK2LMNA | |
| SCHEMBL20040339 | 0.77 | HCRTR1 (0.67) | KMT2AHCRTR1HCRTR2SPHK2LMNA | |
| SCHEMBL4480837 | 0.76 | TP53 (0.60) | KMT2AHCRTR1HCRTR2SPHK2LMNA | |
| SCHEMBL4480840 | 0.76 | TP53 (0.60) | KMT2AHCRTR1HCRTR2SPHK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |