Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538915 | 1.00 | PREP (0.64) | PREPALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8636646 | 0.80 | PREP (0.69) | PREPKMT2APOLBHRH3APEX1 | |
| SCHEMBL8635557 | 0.80 | PREP (0.69) | PREPALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8636651 | 0.80 | PREP (0.69) | PREPKMT2APOLBHRH3APEX1 | |
| SCHEMBL8634319 | 0.79 | GAA (0.45) | — | |
| SCHEMBL9536551 | 0.77 | KMT2A (0.51) | ALDH1A1KMT2ACYP2C19POLB | |
| SCHEMBL9753642 | 0.77 | KMT2A (0.51) | ALDH1A1KMT2ACYP2C19POLB | |
| SCHEMBL9069914 | 0.76 | CA2 (0.49) | ALDH1A1 | |
| SCHEMBL11901003 | 0.71 | KMT2A (0.89) | KMT2ACYP3A4CYP2C9CYP2C19APEX1 | |
| SCHEMBL31680569 | 0.71 | KMT2A (0.89) | KMT2ACYP3A4CYP2C9CYP2C19APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |