Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694140 | 0.92 | ALDH1A1 (0.59) | PPARGPTGS2PTGS1ALDH1A1TRPC3 | |
| SCHEMBL8688557 | 0.89 | PTGS2 (0.52) | PTGS2PTGS1ALDH1A1TRPC3CYP2C9 | |
| SCHEMBL8693708 | 0.86 | POLB (0.67) | PTGS2PTGS1ALDH1A1TRPC3CYP2C9 | |
| SCHEMBL8689312 | 0.81 | PPARG (0.51) | PPARGPTGS2PTGS1ALDH1A1CYP2C9 | |
| SCHEMBL8506431 | 0.79 | PPARG (0.48) | PPARGALDH1A1NR3C1AROXTR | |
| SCHEMBL8500983 | 0.77 | PPARG (0.42) | PPARGALDH1A1CYP2C9NR3C1AR | |
| SCHEMBL27955904 | 0.76 | PTGS2 (0.51) | PTGS2PTGS1CYP2C9KCNJ6KCNJ5 | |
| Hydrochloric Acid SCHEMBL27955937 | 0.74 | PTGS2 (0.50) | PTGS2PTGS1CYP2C9KCNJ6KCNJ5 | |
| SCHEMBL1781529 | 0.74 | KCNJ6 (0.54) | KCNJ6KCNJ5KCNJ3POLB | |
| SCHEMBL8691662 | 0.73 | ALDH1A1 (0.57) | PPARGPTGS2PTGS1ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | claimed |
| EP-0856055-A1 | STREPTAVIDIN MUTANTS | TRUSTEES OF BOSTON UNIVERSITY (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997011183-A1 | STREPTAVIDIN MUTANTS | TRUSTEES OF BOSTON UNIVERSITY (US) | 1997-03-27 | — | — | WO | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |