Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 9/20 | 0.59 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041975 | 0.85 | CCKBR (0.42) | CCKBRSLC6A2SMN1; SMN2KDM4EGAA | |
| SCHEMBL4424441 | 0.80 | GAA (0.46) | SLC6A2KDM4EGAAMAOAALDH1A1 | |
| SCHEMBL8547144 | 0.79 | CCKBR (0.60) | CCKBRSMN1; SMN2 | |
| SCHEMBL8639243 | 0.76 | CCKBR (0.59) | CCKBRSLC6A2CCKARKMT2A | |
| SCHEMBL8638271 | 0.75 | CCKBR (1.00) | CCKBRCCKAR | |
| SCHEMBL4416338 | 0.74 | GABRP (0.46) | CCKBRSLC6A2KDM4EGAAMAOA | |
| SCHEMBL7041976 | 0.74 | CCKBR (0.50) | CCKBRELANESLC6A2SMN1; SMN2CCKAR | |
| SCHEMBL8617340 | 0.72 | CCKBR (0.44) | CCKBRSMN1; SMN2CCKAR | |
| SCHEMBL8897693 | 0.72 | CCKBR (0.60) | CCKBRELANESLC6A2SMN1; SMN2CCKAR | |
| SCHEMBL4415567 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558104-B1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO WELLCOME SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| US-5637697-A | ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ | GLAXO SPA (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5580895-A | GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO SPA (IT) | 1996-12-03 | — | — | US | disclosed |
| EP-0558104-A1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO S.p.A. (IT) | 1993-09-01 | — | — | EP | disclosed |