Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CPS1 | P31327 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635044 | 0.98 | MTNR1B (0.65) | MTNR1BSLC6A4HTR1AKDM4EALDH1A1 | |
| SCHEMBL8637331 | 0.95 | MTNR1B (0.71) | MTNR1BSLC6A4HTR1AKDM4EALDH1A1 | |
| SCHEMBL8635640 | 0.87 | SLC6A4 (0.60) | MTNR1BSLC6A4HTR1AKMT2ACPS1 | |
| SCHEMBL8638699 | 0.84 | HTR1A (0.56) | MTNR1BSLC6A4HTR1AKMT2ACPS1 | |
| SCHEMBL8635447 | 0.84 | MTNR1B (0.67) | MTNR1BSLC6A4HTR1ALMNAKMT2A | |
| SCHEMBL8636963 | 0.83 | HTR1A (0.61) | MTNR1BSLC6A4HTR1AKMT2A | |
| SCHEMBL8633694 | 0.83 | SLC6A4 (0.55) | MTNR1BSLC6A4HTR1AKMT2ACPS1 | |
| SCHEMBL8635354 | 0.83 | SLC6A4 (0.55) | MTNR1BSLC6A4HTR1AKMT2ACPS1 | |
| SCHEMBL8637276 | 0.82 | SLC6A4 (0.54) | MTNR1BSLC6A4HTR1AKMT2ACPS1 | |
| SCHEMBL8635648 | 0.81 | SLC6A4 (0.53) | MTNR1BSLC6A4HTR1AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | claimed |
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | disclosed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5530012-A | FOR SLEEP DISORDERS, DEPRESSION, GLAUCOMA, CANCER | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-25 | — | — | US | disclosed |