Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | EED | O75530 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637987 | 0.86 | EED (0.68) | CCR3ALDH1A1EEDKMT2AMEN1 | |
| SCHEMBL8637780 | 0.84 | HTR1A (0.49) | HTR1ASLC6A4CCR3ALDH1A1KMT2A | |
| SCHEMBL8636409 | 0.83 | KDM4E (0.61) | HTR1ASLC6A4CCR3ALDH1A1EED | |
| SCHEMBL8634509 | 0.82 | CCR3 (0.59) | HTR1ASLC6A4CCR3EEDKMT2A | |
| SCHEMBL8634239 | 0.82 | CCR3 (0.64) | HTR1ASLC6A4CCR3EEDKMT2A | |
| SCHEMBL8635354 | 0.80 | SLC6A4 (0.55) | HTR1ASLC6A4KMT2AMEN1MTNR1B | |
| SCHEMBL16825188 | 0.80 | TGFBR1 (0.56) | HTR1ASLC6A4CCR3ALDH1A1EED | |
| SCHEMBL28299238 | 0.79 | HTR1A (0.77) | HTR1ASLC6A4SIGMAR1 | |
| SCHEMBL5358802 | 0.78 | CCR3 (0.71) | HTR1ASLC6A4CCR3KMT2AMEN1 | |
| SCHEMBL14421472 | 0.78 | HTR1A (0.71) | HTR1ASLC6A4EEDSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | claimed |