Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CCR3 | P51677 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636890 | 0.86 | HTR1A (0.56) | EEDNPC1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8636411 | 0.84 | EED (0.67) | EEDPOLBALDH1A1L3MBTL1CCR3 | |
| SCHEMBL7316755 | 0.81 | DRD2 (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6989129 | 0.77 | EED (0.60) | EEDNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL9600780 | 0.76 | TACR3 (0.67) | EEDRAB9ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL27962885 | 0.75 | EED (0.49) | EEDSMN1; SMN2ALDH1A1CCR3MEN1 | |
| SCHEMBL6953209 | 0.74 | TACR1 (0.52) | ALDH1A1KMT2A | |
| SCHEMBL6959582 | 0.74 | TACR1 (0.52) | EEDNPC1ALDH1A1CCR3MEN1 | |
| SCHEMBL25698257 | 0.74 | EED (0.71) | EEDALDH1A1LMNAPKM | |
| SCHEMBL22813680 | 0.74 | SIGMAR1 (0.62) | NPC1SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | claimed |
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | disclosed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5530012-A | FOR SLEEP DISORDERS, DEPRESSION, GLAUCOMA, CANCER | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-25 | — | — | US | disclosed |