SCHEMBL863696

SCHEMBL863696

Nc1ncnc2c1ncn2C1C=C(C(=O)O)C(O)C1O

nearest known ligand 0.69

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AHCY P23526 14/20 0.69
HIF1A Q16665 1/20 0.55
TMEM97 Q5BJF2 1/20 0.55
SIGMAR1 Q99720 1/20 0.55
HSP90B1 P14625 1/20 0.52
ADORA2A P29274 1/20 0.52
ADORA2B P29275 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10051880 0.83 AHCY (0.74) AHCYHIF1ATMEM97SIGMAR1HSP90B1
SCHEMBL26382114 0.83 AHCY (0.74) AHCYADORA2A
SCHEMBL12281124 0.82 AHCY (1.00) AHCYADORA2A
SCHEMBL26382111 0.82 AHCY (1.00) AHCYADORA2A
Hydrochloric Acid SCHEMBL1935723 0.81 AHCY (0.97) AHCYADORA2A
SCHEMBL864418 0.80 AHCY (0.81) AHCY
SCHEMBL12280561 0.80 AHCY (0.81) AHCY
Neoplanocin A SCHEMBL10576831 0.80 AHCY (1.00) AHCYADORA2AADORA2B
Neoplanocin A SCHEMBL10469277 0.80 AHCY (1.00) AHCYADORA2AADORA2B
Neoplanocin A SCHEMBL863873 0.80 AHCY (1.00) AHCYADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2522352-B1 Methods for stem cells modulation AGENCY SCIENCE TECH & RES (SG) 2017-01-11 EP disclosed
EP-1993553-B1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION AGENCY SCIENCE TECH & RES (SG) 2013-05-08 EP disclosed
EP-2522352-A1 Methods for cancer therapy and stem cell modulation Agency for Science, Technology and Research (SG) 2012-11-14 EP disclosed
US-8211869-B2 Methods for cancer therapy and stem cell modulation AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2012-07-03 US disclosed
US-20120077841-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2012-03-29 US disclosed
US-8058258-B2 Methods for cancer therapy and stem cell modulation AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2011-11-15 US disclosed
US-20100075915-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2010-03-25 US disclosed
EP-1993553-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION Agency for Science, Technology and Research (SG) 2008-11-26 EP disclosed
WO-2007100304-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2007-09-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100075915-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION MCL1, BCOR, BCL2 AHCY 2998/4885HIF1A 204/4885TMEM97 1393/4885
US-20120077841-A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION HCCS, MCL1, AHR AHCY 1749/4885HIF1A 99/4885TMEM97 2186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.