Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639404 | 0.90 | LTA4H (0.46) | LTA4HHRH3 | |
| SCHEMBL8188491 | 0.77 | NPC1 (0.50) | — | |
| SCHEMBL1802067 | 0.75 | LTA4H (0.58) | LTA4HHRH3 | |
| SCHEMBL7246915 | 0.72 | NPC1 (0.45) | — | |
| SCHEMBL503024 | 0.71 | NPC1 (0.39) | — | |
| SCHEMBL7322832 | 0.71 | SLC2A1 (0.59) | LTA4HHRH3 | |
| SCHEMBL27996343 | 0.70 | LTA4H (0.49) | LTA4HHRH3 | |
| SCHEMBL27996276 | 0.70 | LTA4H (0.49) | LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7321449 | 0.70 | SLC2A1 (0.58) | LTA4HHRH3 | |
| SCHEMBL7330703 | 0.70 | HRH3 (0.52) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |