Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637065 | 0.90 | LTA4H (0.44) | LTA4HHRH3 | |
| SCHEMBL8188491 | 0.87 | NPC1 (0.50) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7246915 | 0.83 | NPC1 (0.45) | NPC1RAB9AHPGD | |
| SCHEMBL1802067 | 0.74 | LTA4H (0.58) | LTA4HHRH3 | |
| SCHEMBL503024 | 0.73 | NPC1 (0.39) | NPC1RAB9AHPGD | |
| SCHEMBL3124205 | 0.71 | ALDH1A1 (0.40) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7322832 | 0.70 | SLC2A1 (0.59) | LTA4HHRH3 | |
| SCHEMBL7142157 | 0.70 | CHRNB2 (0.38) | NPC1RAB9AHPGD | |
| SCHEMBL8637445 | 0.69 | HRH1 (0.46) | LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7321449 | 0.69 | SLC2A1 (0.58) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |