Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648834 | 0.80 | MAOA (0.44) | SMN1; SMN2NPC1RAB9AMAOAMAOB | |
| SCHEMBL156160 | 0.79 | MAOA (0.54) | SMN1; SMN2NPC1RAB9AMAOAMAOB | |
| SCHEMBL7166167 | 0.79 | GAA (0.49) | SMN1; SMN2MAPK1MAPTMAOAMAOB | |
| SCHEMBL9465836 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2MAPK1MAPTKMT2AHSD11B1 | |
| SCHEMBL7810604 | 0.77 | MAOA (0.44) | SMN1; SMN2NPC1RAB9AMAOAMAOB | |
| SCHEMBL9181453 | 0.76 | KMT2A (0.41) | SMN1; SMN2NPC1RAB9AMAOAMAOB | |
| SCHEMBL4904341 | 0.76 | GAA (0.52) | SMN1; SMN2NPC1RAB9AMAPTMAOA | |
| SCHEMBL7384480 | 0.75 | NPC1 (0.41) | KEAP1SMN1; SMN2NPC1RAB9AHDAC3 | |
| SCHEMBL7818237 | 0.75 | GAA (0.43) | SMN1; SMN2NPC1RAB9AMAOAMAOB | |
| SCHEMBL8347115 | 0.75 | MAOA (0.54) | SMN1; SMN2NPC1RAB9AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064356-C | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | CN | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| CN-1142494-A | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 1997-02-12 | — | — | CN | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |