Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644125 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1PDPK1CHRNA7RXRA | |
| SCHEMBL8640280 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1PDPK1CHRNA7RXRA | |
| SCHEMBL8637676 | 0.86 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8637650 | 0.86 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL9014927 | 0.86 | PTGS2 (0.56) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8639798 | 0.84 | PTGS2 (0.66) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8639018 | 0.83 | PTGS2 (0.55) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL6339043 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1PDPK1CHRNA7 | |
| SCHEMBL8637364 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1PDPK1RXRANR1H2 | |
| SCHEMBL8639277 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1PDPK1CHRNA7CACNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |