Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878985 | 0.78 | FKBP1A (0.58) | LTA4HMEN1KMT2APOLBFKBP1A | |
| SCHEMBL15626755 | 0.78 | FKBP1A (0.58) | LTA4HMEN1KMT2APOLBFKBP1A | |
| SCHEMBL13832798 | 0.78 | FKBP1A (0.58) | LTA4HMEN1KMT2APOLBFKBP1A | |
| SCHEMBL8644158 | 0.77 | LTA4H (0.60) | LTA4HL3MBTL1 | |
| SCHEMBL8640066 | 0.76 | LTA4H (0.56) | LTA4HALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7142480 | 0.75 | LTA4H (1.00) | LTA4HMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8637340 | 0.74 | LTA4H (0.63) | LTA4H | |
| SCHEMBL26694862 | 0.74 | POLB (0.53) | LTA4HMEN1KMT2APOLBSPHK1 | |
| SCHEMBL8641249 | 0.73 | LTA4H (0.47) | LTA4HMEN1KMT2ASPHK1HRH3 | |
| SCHEMBL7137211 | 0.72 | LTA4H (0.71) | LTA4HMEN1KMT2AHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |