SCHEMBL8637389

SCHEMBL8637389

Cc1ccc(-c2cc(C(F)(F)F)nn2NS(=O)(=O)c2ccccc2)c(C)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 9/20 0.53
PTGS1 P23219 7/20 0.53
PTGES O14684 2/20 0.43
FFAR4 Q5NUL3 1/20 0.40
TRPC3 Q13507 1/20 0.39
CYP2C9 P11712 2/20 0.38
ALOX5 P09917 2/20 0.38
PDPK1 O15530 2/20 0.38
HDAC3 O15379 1/20 0.38
CA12 O43570 1/20 0.38
PDE5A O76074 1/20 0.38
ABCB11 O95342 1/20 0.38
MT-CO2 P00403 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
LMNA P02545 1/20 0.38
CA3 P07451 1/20 0.38
CYP3A4 P08684 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8639807 0.91 PTGS2 (0.43) PTGS2PTGS1PTGESTRPC3CYP2C9
SCHEMBL726057 0.91 PTGES (0.53) PTGS2PTGS1PTGESFFAR4TRPC3
SCHEMBL8643950 0.90 PTGS2 (0.43) PTGS2PTGS1
SCHEMBL8639293 0.90 PTGS2 (0.54) PTGS2PTGS1PTGESFFAR4PDPK1
SCHEMBL8644138 0.89 PTGS2 (0.42) PTGS2PTGS1PTGESTRPC3CYP2C9
SCHEMBL8640002 0.89 PTGS2 (0.42) PTGS2PTGS1PDPK1
SCHEMBL7135445 0.85 PTGS2 (0.51) PTGS2PTGS1PTGESTRPC3CYP2C9
SCHEMBL8689593 0.84 PTGS2 (0.39) PTGS2PTGS1PTGESTRPC3CYP2C9
SCHEMBL6512523 0.83 KAT6A (0.43) PTGS2PTGS1TSHR
SCHEMBL8638531 0.83 PTGS2 (0.54) PTGS2PTGS1PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5760068-A NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS G.D. SEARLE & CO. (US) 1998-06-02 US claimed
US-5760068-A NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS G.D. SEARLE & CO. (US) 1998-06-02 US disclosed
US-5756529-A ANTIINFLAMMATORY G.D. SEARLE & CO. (US) 1998-05-26 US disclosed
US-5753688-A ANTIINFLAMMATORY TALLEY JOHN J (US) 1998-05-19 US disclosed
US-5510496-A ANTIINFLAMMATORY AGENTS G.D. SEARLE & CO. (US) 1996-04-23 US disclosed
US-5504215-A Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation G. D. SEARLE & CO. (US) 1996-04-02 US disclosed