Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637389 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1PTGESTRPC3CYP2C9 | |
| SCHEMBL8635926 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL8639807 | 0.89 | PTGS2 (0.43) | PTGS2PTGS1PTGESTRPC3CYP2C9 | |
| SCHEMBL8641739 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL726057 | 0.87 | PTGES (0.53) | PTGS2PTGS1PTGESTRPC3TDP1 | |
| SCHEMBL8641607 | 0.86 | PDPK1 (0.45) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL8641742 | 0.86 | PTGS2 (0.40) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL8640002 | 0.85 | PTGS2 (0.42) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL8643712 | 0.84 | PTGS2 (0.41) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL8638989 | 0.83 | PTGS2 (0.42) | PTGS2PTGS1RXRANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |