Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 11/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637456 | 0.90 | LTA4H (0.46) | HRH1LTA4HHRH3SIGMAR1 | |
| SCHEMBL4322788 | 0.89 | MEN1 (0.39) | — | |
| SCHEMBL8641764 | 0.88 | HRH3 (0.50) | LTA4HHRH3SIGMAR1 | |
| Benzene SCHEMBL8637783 | 0.85 | LTA4H (0.48) | HRH1LTA4HHRH3SIGMAR1 | |
| SCHEMBL8639588 | 0.85 | LTA4H (0.48) | HRH1LTA4HHRH3SIGMAR1 | |
| SCHEMBL7398930 | 0.85 | HRH3 (0.43) | HRH1LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7397620 | 0.84 | KCNH2 (0.43) | HRH1LTA4HHRH3 | |
| SCHEMBL7246918 | 0.84 | CARM1 (0.40) | — | |
| SCHEMBL8644129 | 0.84 | LMNA (0.41) | LTA4HHRH3 | |
| SCHEMBL8639270 | 0.84 | LTA4H (0.44) | LTA4HHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |