Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640957 | 0.89 | LTA4H (0.41) | LMNASMN1; SMN2RECQLHRH3LTA4H | |
| SCHEMBL8640526 | 0.88 | LMNA (0.48) | LMNASMN1; SMN2RECQLHRH3SPHK2 | |
| SCHEMBL8637775 | 0.88 | MAOA (0.44) | SMN1; SMN2HRH3SPHK2SPHK1CARM1 | |
| SCHEMBL8639270 | 0.86 | LTA4H (0.44) | HRH3SPHK2SPHK1CARM1PRMT6 | |
| SCHEMBL8637445 | 0.84 | HRH1 (0.46) | HRH3LTA4H | |
| SCHEMBL8640950 | 0.84 | SCN3A (0.43) | LMNASMN1; SMN2RECQLSPHK2SPHK1 | |
| SCHEMBL8640569 | 0.82 | LTA4H (0.48) | HRH3LTA4H | |
| SCHEMBL8641269 | 0.82 | LTA4H (0.48) | HRH3LTA4H | |
| SCHEMBL8641109 | 0.80 | LTA4H (0.52) | HRH3SPHK2LTA4HALDH1A1 | |
| SCHEMBL8637805 | 0.80 | HRH3 (0.47) | LMNASMN1; SMN2RECQLHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |