Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850348 | 0.89 | TSHR (0.59) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL6821944 | 0.85 | TSHR (0.58) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL8499877 | 0.84 | TSHR (0.57) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL530075 | 0.81 | TSHR (0.61) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL135651 | 0.77 | TSHR (0.59) | TSHRMAPTKMT2AKCNJ1ALDH1A1 | |
| SCHEMBL28066215 | 0.76 | TSHR (0.47) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL7717557 | 0.76 | TSHR (0.51) | TSHRMAPTKMT2AKCNJ1ALDH1A1 | |
| SCHEMBL8934569 | 0.75 | TSHR (0.58) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL5030925 | 0.75 | TSHR (0.58) | TSHRMAPTKMT2ALOXL2KCNJ1 | |
| SCHEMBL7733298 | 0.75 | TSHR (0.58) | TSHRMAPTKMT2ALOXL2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832111-A4 | MODIFIED AVIDIN AND STREPTAVIDIN AND METHODS OF USE THEREOF | ROSEBROUGH SCOTT F (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0832111-A1 | MODIFIED AVIDIN AND STREPTAVIDIN AND METHODS OF USE THEREOF | Rosebrough, Scott F. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040761-A9 | MODIFIED AVIDIN AND STREPTAVIDIN AND METHODS OF USE THEREOF | — | 1997-01-30 | — | — | WO | disclosed |
| WO-1996040761-A1 | MODIFIED AVIDIN AND STREPTAVIDIN AND METHODS OF USE THEREOF | ROSEBROUGH SCOTT F (US) | 1996-12-19 | — | — | WO | disclosed |