Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nornitrogen Mustard SCHEMBL8637079 | 0.78 | KMT2A (0.52) | CES2FLT1FLT4KDRMAPT | |
| Nornitrogen Mustard SCHEMBL8638765 | 0.75 | KDM4E (0.49) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL8640126 | 0.74 | MAPT (0.45) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL8637404 | 0.74 | FLT1 (0.51) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL3126462 | 0.72 | CES2 (0.59) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL8639694 | 0.72 | MAPT (0.43) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL5341177 | 0.71 | CES2 (0.63) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL1176899 | 0.71 | CTSD (0.63) | CES2FLT1FLT4KDRMAPT | |
| SCHEMBL8641420 | 0.70 | POLB (0.44) | CES2FLT1FLT4KDRMAPT | |
| Hydrochloric Acid SCHEMBL10973904 | 0.70 | CES2 (0.42) | CES2FLT1FLT4KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183062-B2 | Treatment for cancer | THE UNIVERSITY OF NOTTINGHAM (GB) | 2019-01-22 | — | — | US | claimed |
| WO-2015075475-A1 | TREATMENT FOR CANCER | THE UNIVERSITY OF NOTTINGHAM (GB) | 2015-05-28 | — | — | WO | claimed |
| WO-2015075475-A1 | TREATMENT FOR CANCER | THE UNIVERSITY OF NOTTINGHAM (GB) | 2015-05-28 | — | — | WO | disclosed |
| US-5750782-A | ANTICARCINOGENIC AGENTS, ANTIHYPOXIC AGENTS, PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |