Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689478 | 0.92 | PTGS2 (0.53) | PTGS1PTGS2MAPTALDH1A1 | |
| SCHEMBL8204244 | 0.89 | PTGS1 (0.51) | PTGS1PTGS2KDM1ALMNANPSR1 | |
| SCHEMBL8640282 | 0.87 | PTGS1 (0.53) | PTGS1PTGS2KDM1ALMNANPSR1 | |
| SCHEMBL8689002 | 0.84 | PTGS1 (0.55) | PTGS1PTGS2ALDH1A1HTTSMN1; SMN2 | |
| Benzenesulfonamide SCHEMBL7051156 | 0.84 | PTGS2 (0.60) | PTGS1PTGS2 | |
| SCHEMBL8423988 | 0.84 | PTGES (0.43) | KDM1ALMNANPSR1MAPTALDH1A1 | |
| SCHEMBL8421861 | 0.81 | PTGES (0.41) | PTGS1PTGS2KDM1ALMNANPSR1 | |
| SCHEMBL6520729 | 0.81 | PTGS2 (0.42) | PTGS1PTGS2LMNAMAPTALDH1A1 | |
| SCHEMBL8639075 | 0.79 | PTGS2 (0.41) | PTGS1PTGS2LMNANPSR1MAPT | |
| SCHEMBL8692558 | 0.78 | PTGS2 (0.41) | PTGS1PTGS2MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |