Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692558 | 0.92 | PTGS2 (0.41) | PTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8688419 | 0.91 | MAPT (0.45) | PTGS1PTGS2ALDH1A1HTTNPSR1 | |
| SCHEMBL8639075 | 0.90 | PTGS2 (0.41) | PTGS1PTGS2ALDH1A1LMNANPSR1 | |
| SCHEMBL8204244 | 0.88 | PTGS1 (0.51) | PTGS1PTGS2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8637642 | 0.87 | PTGS1 (0.46) | PTGS1PTGS2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8689103 | 0.87 | LMNA (0.43) | PTGS1PTGS2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8689002 | 0.86 | PTGS1 (0.55) | PTGS1PTGS2TP53ALDH1A1HTT | |
| Benzenesulfonamide SCHEMBL7051156 | 0.84 | PTGS2 (0.60) | PTGS1PTGS2 | |
| SCHEMBL8424177 | 0.83 | PTGES (0.43) | TP53ALDH1A1SMN1; SMN2KDM1ALMNA | |
| SCHEMBL8163016 | 0.81 | PTGS2 (0.41) | PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |