Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863779 | 1.00 | ATM (0.36) | ATMPIK3CDCDK1CDK5 | |
| SCHEMBL863366 | 0.79 | PIK3CD (0.35) | ATMPIK3CDCDK1CDK5 | |
| SCHEMBL864806 | 0.77 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL864807 | 0.77 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL3656008 | 0.70 | DRD4 (0.45) | ATMPIK3CD | |
| SCHEMBL717941 | 0.70 | DRD4 (0.45) | ATMPIK3CD | |
| SCHEMBL15184812 | 0.67 | PIK3CD (0.39) | PIK3CD | |
| SCHEMBL15184813 | 0.67 | PIK3CD (0.39) | PIK3CD | |
| SCHEMBL25847026 | 0.65 | GABRA1 (0.34) | — | |
| SCHEMBL845236 | 0.64 | ALOX15 (0.59) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513284-B2 | Fused pyridine and pyrazine derivatives as kinase inhibitors | UCB PHARMA, S.A. (BE) | 2013-08-20 | — | — | US | disclosed |
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | PDPK1, PDXK, PIK3CA | ATM 357/4885PIK3CD 14/4885CDK1 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.