Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.54 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.53 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.53 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637850 | 1.00 | SPHK1 (0.54) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL19603949 | 0.89 | GNAO1 (0.63) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL1891298 | 0.89 | GNAO1 (0.63) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL19275229 | 0.89 | GNAO1 (0.63) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL6222192 | 0.89 | GNAO1 (0.63) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL4250726 | 0.88 | GNAO1 (0.60) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL15212251 | 0.84 | GNAI3 (0.59) | GNAO1GNAI3GNAI1 | |
| SCHEMBL1698806 | 0.82 | SPHK1 (0.57) | SPHK1GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL8639461 | 0.81 | BCHE (0.52) | GNAO1GNAI3GNAI1GUSB | |
| SCHEMBL8639464 | 0.81 | BCHE (0.52) | GNAO1GNAI3GNAI1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650474-B1 | NOVEL PIPERIDYL AMIDES, SULFONAMIDES AND SULFOXAMIDES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | MERRELL PHARMA INC (US) | 1998-08-12 | — | — | EP | claimed |