Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 11/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641804 | 0.93 | TAAR1 (0.59) | TAAR1LTA4HCYP2D6CYP1A2CYP2C9 | |
| SCHEMBL8637323 | 0.88 | TAAR1 (0.53) | TAAR1LTA4HCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL11581355 | 0.88 | TAAR1 (0.53) | TAAR1LTA4HCYP2D6CYP1A2CYP2C9 | |
| SCHEMBL8639331 | 0.85 | LTA4H (0.49) | TAAR1LTA4HCYP2D6CYP1A2CYP2C9 | |
| SCHEMBL8685448 | 0.82 | CYP1A2 (0.48) | TAAR1LTA4HCYP2D6CYP1A2CYP2C9 | |
| SCHEMBL8690542 | 0.81 | CYP3A4 (0.50) | TAAR1LTA4HCYP2D6CYP1A2CYP2C9 | |
| SCHEMBL11702882 | 0.81 | TAAR1 (0.73) | TAAR1LTA4HCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL8685427 | 0.79 | GAA (0.56) | LTA4HHTTL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL8690250 | 0.78 | HRH3 (0.48) | CYP2D6CYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL8684972 | 0.78 | FPR2 (0.43) | TAAR1CYP2D6CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |