Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11581355 | 0.94 | TAAR1 (0.53) | LTA4HTAAR1KCNA3HRH3CYP1A2 | |
| SCHEMBL8637455 | 0.92 | LTA4H (0.51) | LTA4HPLA2G2ATAAR1KCNA3HRH3 | |
| SCHEMBL8535825 | 0.90 | LTA4H (0.50) | LTA4HPLA2G2ATAAR1KCNA3HRH3 | |
| SCHEMBL8635977 | 0.88 | LTA4H (0.44) | LTA4HCYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8638258 | 0.85 | TAAR1 (0.61) | LTA4HTAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8637323 | 0.85 | TAAR1 (0.53) | LTA4HTAAR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8685427 | 0.81 | GAA (0.56) | LTA4HHRH3 | |
| SCHEMBL8690250 | 0.81 | HRH3 (0.48) | HRH3CYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL6181232 | 0.81 | NPC1 (0.49) | TAAR1CYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8684972 | 0.81 | FPR2 (0.43) | TAAR1CYP1A2CYP3A4CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |