Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | KCNN3 | Q9UGI6 | 10/20 | 0.36 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.36 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31625491 | 0.79 | PDE10A (0.52) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL5421748 | 0.79 | PDE10A (0.42) | PDE10AKCNN3KCNN1KCNN2CHEK1 | |
| SCHEMBL30363704 | 0.76 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2CHEK1 | |
| SCHEMBL7493929 | 0.76 | PDE10A (0.40) | PDE10AKCNN3CHEK1CCNA2CDK2 | |
| SCHEMBL25421401 | 0.72 | PDE10A (0.37) | PDE10AKCNN3CHEK1CCNA2CDK2 | |
| SCHEMBL18478012 | 0.72 | DGAT1 (0.40) | PDE10AKCNN3CCNA2CDK2CCNA1 | |
| SCHEMBL7490786 | 0.72 | PRKAB2 (0.37) | PDE10AKCNN3KCNN1KCNN2CHEK1 | |
| SCHEMBL15232215 | 0.72 | NPC1 (0.51) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL1018372 | 0.71 | PDE10A (0.67) | PDE10AKCNN3KCNN1KCNN2CHEK1 | |
| SCHEMBL30974 | 0.71 | PDE10A (0.67) | PDE10AKCNN3KCNN1KCNN2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513284-B2 | Fused pyridine and pyrazine derivatives as kinase inhibitors | UCB PHARMA, S.A. (BE) | 2013-08-20 | — | — | US | disclosed |
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | PDPK1, PDXK, PIK3CA | PDE10A 1743/4885KCNN3 1241/4885KCNN1 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.