SCHEMBL8638538

SCHEMBL8638538

Cc1cc(Oc2ccc(Cl)cc2)cc(C)c1OCC=C(Cl)Cl

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.40
SCN9A Q15858 1/20 0.36
MAOB P27338 2/20 0.35
MAOA P21397 1/20 0.35
PPARD Q03181 2/20 0.34
MCL1 Q07820 4/20 0.34
SLC2A1 P11166 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8634588 0.87 SCN9A (0.35) SCN9AMAOBMAOAPPARDMCL1
SCHEMBL8635753 0.85 HTT (0.38) HTTSCN9AMAOBMAOAFFAR4
SCHEMBL8661536 0.82 HTT (0.43) HTTMAOBPPARDMCL1FFAR4
SCHEMBL8408870 0.77 HTT (0.40) HTTPPARDMCL1
SCHEMBL8659512 0.77 HTT (0.40) HTTPPARDMCL1FFAR4
SCHEMBL8635684 0.75 TDP1 (0.42) HTTMAOBMAOAPPARD
SCHEMBL10513154 0.75 LTA4H (0.38) SCN9AMAOBMAOAFFAR4
SCHEMBL8637054 0.74 HTT (0.40) HTTMAOBMAOAPPARDFFAR4
SCHEMBL8661408 0.74 HTT (0.41) HTTPPARDMCL1
SCHEMBL7976362 0.74 HTT (0.41) HTTFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed