Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643957 | 0.94 | MAPT (0.40) | KDM4EPGRHTTMAPK1MALT1 | |
| SCHEMBL8642039 | 0.90 | MALT1 (0.40) | KDM4EMALT1ALDH1A1MAPTHPGD | |
| SCHEMBL8640970 | 0.87 | BRD4 (0.38) | KDM4EHTTMAPK1MALT1PTGDR2 | |
| SCHEMBL8637326 | 0.86 | MALT1 (0.39) | HTTMALT1PTGDR2ALDH1A1MAPT | |
| SCHEMBL8636863 | 0.84 | PTGS2 (0.42) | HTTMALT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8639208 | 0.83 | CA12 (0.43) | MALT1ALDH1A1SMN1; SMN2KDM1A | |
| SCHEMBL8641617 | 0.83 | LMNA (0.43) | KDM4EHTTMALT1ALDH1A1MAPT | |
| SCHEMBL8639275 | 0.81 | MALT1 (0.44) | HTTMALT1ALDH1A1MAPTLMNA | |
| SCHEMBL8637161 | 0.81 | MALT1 (0.41) | MALT1ALDH1A1MAPTSMN1; SMN2KDM1A | |
| SCHEMBL8643728 | 0.81 | MALT1 (0.39) | MALT1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |