Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638657 | 0.87 | KDM4E (0.42) | SMN1; SMN2MAPTKDM4ELMNAMALT1 | |
| SCHEMBL8642039 | 0.86 | MALT1 (0.40) | SMN1; SMN2MAPTKDM4EMALT1PTGS2 | |
| SCHEMBL8643957 | 0.83 | MAPT (0.40) | SMN1; SMN2MAPTKDM4ELMNAMALT1 | |
| SCHEMBL8637326 | 0.82 | MALT1 (0.39) | MAPTMALT1PTGS2PTGDR2ALDH1A1 | |
| SCHEMBL8636863 | 0.80 | PTGS2 (0.42) | SMN1; SMN2LMNAMALT1PTGS1PTGS2 | |
| SCHEMBL8639208 | 0.79 | CA12 (0.43) | SMN1; SMN2MALT1PTGS2ALDH1A1GAA | |
| SCHEMBL8641617 | 0.79 | LMNA (0.43) | SMN1; SMN2MAPTKDM4ELMNAMALT1 | |
| SCHEMBL8639275 | 0.78 | MALT1 (0.44) | SMN1; SMN2MAPTLMNAMALT1ALDH1A1 | |
| SCHEMBL8420848 | 0.77 | PTGS2 (0.46) | KDM4ELMNAMALT1PTGS1PTGS2 | |
| SCHEMBL8637161 | 0.77 | MALT1 (0.41) | SMN1; SMN2MAPTMALT1PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |