Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8646256 | 0.95 | MTNR1A (0.55) | MTNR1AMTNR1BALDH1A1NQO2KDM4E | |
| SCHEMBL8643820 | 0.95 | MTNR1A (0.58) | MTNR1AMTNR1BALDH1A1NQO2KDM4E | |
| SCHEMBL8643878 | 0.93 | MTNR1A (0.52) | MTNR1AMTNR1BALDH1A1NQO2KDM4E | |
| SCHEMBL8643655 | 0.88 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1NQO2KDM4E | |
| SCHEMBL8646700 | 0.84 | MTNR1A (0.61) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8643630 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8639949 | 0.82 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL8646238 | 0.81 | MTNR1A (0.48) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8641737 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BALDH1A1NQO2KDM4E | |
| SCHEMBL9017429 | 0.81 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1NQO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736578-A | TREATMENT OF SLEEP DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-07 | — | — | US | claimed |
| CN-1145895-A | New amido-ethyl substituted fluorene compound and its prepn. | BRISTOL MYERS SQUIBB CO (US) | 1997-03-26 | — | — | CN | claimed |
| EP-0747345-A2 | Ethylamido fluorenes and improved method of making same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| US-5736578-A | TREATMENT OF SLEEP DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| CN-1145895-A | New amido-ethyl substituted fluorene compound and its prepn. | BRISTOL MYERS SQUIBB CO (US) | 1997-03-26 | — | — | CN | disclosed |
| EP-0747345-A2 | Ethylamido fluorenes and improved method of making same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |