Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638192 | 0.90 | TAAR1 (0.42) | PTGS2PTGS1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL8637418 | 0.89 | MEN1 (0.36) | PTGS2PTGS1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL8643560 | 0.85 | HTT (0.39) | PTGS2PTGS1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL8688627 | 0.85 | PTGS2 (0.44) | PTGS2PTGS1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL8639075 | 0.84 | PTGS2 (0.41) | PTGS2PTGS1NPSR1LMNANR3C1 | |
| SCHEMBL8693949 | 0.83 | PTGS1 (0.44) | PTGS2PTGS1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL8689002 | 0.82 | PTGS1 (0.55) | PTGS2PTGS1HTTSMN1; SMN2 | |
| SCHEMBL8689174 | 0.80 | ALDH1A1 (0.45) | PTGS2PTGS1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL8689171 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1SMN1; SMN2LMNA | |
| SCHEMBL8688468 | 0.80 | PTGS2 (0.39) | PTGS2PTGS1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |