Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.71 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864155 | 0.95 | SIGMAR1 (0.79) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL11193368 | 0.93 | SIGMAR1 (0.77) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL8914175 | 0.90 | SIGMAR1 (0.60) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL11184048 | 0.88 | SIGMAR1 (0.59) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL11257702 | 0.86 | SIGMAR1 (0.71) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL7326095 | 0.83 | SIGMAR1 (1.00) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL11254741 | 0.81 | DRD2 (0.80) | SIGMAR1DRD2HTR2ACYP2D6TSHR | |
| SCHEMBL11176916 | 0.81 | DRD2 (0.62) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL863907 | 0.81 | SIGMAR1 (0.59) | SIGMAR1DRD2HTR2AHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL11543880 | 0.80 | DRD2 (0.78) | SIGMAR1DRD2HTR2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440563-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | Sunovion Pharmaceuticals Inc. (US) | 2012-04-18 | — | — | EP | disclosed |
| US-20120077802-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077802-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | HRH3, HRH4, HRH2 | SIGMAR1 179/4885DRD2 194/4885HTR2A 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.