Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 7/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640497 | 0.89 | SPHK2 (0.50) | SPHK2HRH3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8639328 | 0.89 | HRH3 (0.51) | SPHK2SPHK1HRH3NPC1CASP3 | |
| SCHEMBL8644129 | 0.88 | LMNA (0.41) | LMNASPHK2SPHK1HRH3RECQL | |
| SCHEMBL8640809 | 0.88 | HRH3 (0.47) | SPHK2SPHK1HRH3NPC1RAB9A | |
| SCHEMBL8641777 | 0.87 | HRH3 (0.57) | LMNASPHK2SPHK1HRH3NPC1 | |
| SCHEMBL8636128 | 0.86 | MAOB (0.56) | SPHK2SPHK1MAOBMAOAMMP13 | |
| SCHEMBL8640957 | 0.85 | LTA4H (0.41) | LMNAHRH3RECQLSMN1; SMN2 | |
| SCHEMBL7400750 | 0.83 | HRH3 (0.45) | LMNASPHK2SPHK1HRH3NPC1 | |
| Hydrochloric Acid SCHEMBL7403941 | 0.82 | HRH3 (0.44) | LMNASPHK2SPHK1HRH3NPC1 | |
| SCHEMBL8637785 | 0.81 | SCN3A (0.53) | SPHK2SPHK1NPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |