Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863990 | 0.81 | MET (0.42) | METKDM4ELMNAMAPTHTT | |
| SCHEMBL863591 | 0.78 | MET (0.45) | METKDM4ELMNAMAPTHTT | |
| SCHEMBL2646931 | 0.75 | KDM4E (0.67) | METKDM4ELMNAMAPTHTT | |
| SCHEMBL16174469 | 0.74 | MET (0.43) | METKDM4ELMNAMAPTHTT | |
| SCHEMBL863630 | 0.73 | NPC1 (0.52) | KDM4EHPGDHSD17B10BRD4ADORA3 | |
| SCHEMBL4781296 | 0.70 | LRRK2 (0.47) | METKDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL19626756 | 0.67 | ALDH1A1 (0.49) | KDM4EMAPTHPGDHSD17B10FAAH | |
| SCHEMBL16174464 | 0.67 | MAOB (0.43) | METHSD11B1BRD4FAAHGABRA1 | |
| SCHEMBL11489169 | 0.65 | KDM4E (0.65) | KDM4ELMNAHTTHPGDHSD17B10 | |
| SCHEMBL17626320 | 0.65 | FAAH (0.41) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865719-B2 | Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-21 | — | — | US | disclosed |
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | CHRNA7, CHRNA5, CHRNA1 | MET 4368/4885HSD11B1 1613/4885KDM4E 1296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.