Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641791 | 0.88 | KMT2A (0.50) | MTNR1AMTNR1BSMN1; SMN2LMNANPSR1 | |
| SCHEMBL2173199 | 0.81 | ATM (0.52) | SMN1; SMN2LMNARAB9ANPC1HPGD | |
| SCHEMBL8641832 | 0.79 | P2RX7 (0.43) | MTNR1AMTNR1BSMN1; SMN2LMNARAB9A | |
| SCHEMBL8644340 | 0.77 | MTNR1A (0.41) | MTNR1AMTNR1BSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8641785 | 0.77 | MTNR1A (0.39) | MTNR1AMTNR1BSMN1; SMN2LMNARAB9A | |
| SCHEMBL31682182 | 0.74 | SSTR4 (0.39) | — | |
| SCHEMBL2172656 | 0.74 | ATM (0.57) | SMN1; SMN2HPGDMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5807511 | 0.74 | SLC6A2 (0.42) | — | |
| SCHEMBL14491546 | 0.74 | SMN1; SMN2 (0.55) | MTNR1AMTNR1BSMN1; SMN2LMNANPSR1 | |
| SCHEMBL5810393 | 0.73 | OPRM1 (0.40) | SMN1; SMN2LMNAMAPK1NPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |