Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 9/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815087 | 1.00 | KLK7 (0.50) | KLK7USP2KLK5PSEN1PSEN2 | |
| SCHEMBL29096947 | 0.86 | USP2 (0.49) | KLK7USP2KLK5NR1H2NR1H3 | |
| SCHEMBL29096943 | 0.86 | USP2 (0.49) | KLK7USP2KLK5NR1H2NR1H3 | |
| SCHEMBL8196492 | 0.85 | SMN1; SMN2 (0.44) | KLK7USP2KLK5PRSS1PRSS2 | |
| SCHEMBL16050161 | 0.82 | USP2 (0.53) | KLK7USP2KLK5PSEN1PSEN2 | |
| SCHEMBL16050314 | 0.82 | USP2 (0.53) | KLK7USP2KLK5PSEN1PSEN2 | |
| SCHEMBL16050163 | 0.82 | USP2 (0.53) | KLK7USP2KLK5PSEN1PSEN2 | |
| SCHEMBL7317628 | 0.82 | USP2 (0.67) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5704537 | 0.82 | USP2 (0.67) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27041465 | 0.81 | USP2 (0.46) | USP2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863753-A1 | PERFLUOROALKYL SUBSTITUTED METALLO-BETA-LACTAMASE INHIBITORS AND METHOD FOR THE PREPARATION OF TRIFLUOROMETHYLKETONE DERIVATIVES | ISIS INNOVATION LIMITED (GB) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019681-A1 | PERFLUOROALKYL SUBSTITUTED METALLO-BETA-LACTAMASE INHIBITORS AND METHOD FOR THE PREPARATION OF TRIFLUOROMETHYLKETONE DERIVATIVES | ISIS INNOVATION LIMITED (GB) | 1997-06-05 | — | — | WO | disclosed |