SCHEMBL864029

SCHEMBL864029

CCOCCOc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR4 P22455 13/20 0.80
KDR P35968 5/20 0.80
FGFR1 P11362 4/20 0.80
RET P07949 4/20 0.80
PDGFRB P09619 3/20 0.80
PDGFRA P16234 3/20 0.80
FGFR2 P21802 3/20 0.80
FGFR3 P22607 3/20 0.80
FLT1 P17948 3/20 0.80
FLT4 P35916 3/20 0.80
KIT P10721 2/20 0.80
AURKB Q96GD4 2/20 0.80
RIPK2 O43353 1/20 0.80
ERN1 O75460 1/20 0.80
STK10 O94804 1/20 0.80
MAP3K6 O95382 1/20 0.80
ABL1 P00519 1/20 0.80
ESR1 P03372 1/20 0.80
ADORA3 P0DMS8 1/20 0.80
BCR P11274 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL864156 0.92 FGFR4 (0.85) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL24240683 0.91 FGFR4 (0.80) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL12503490 0.91 FGFR4 (0.65) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL864110 0.91 FGFR4 (0.82) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL1899046 0.90 FGFR4 (0.81) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL19956978 0.89 FGFR4 (0.68) FGFR4KDRFGFR1RETPDGFRB
Lenvatinib SCHEMBL29349806 0.89 FGFR4 (1.00) FGFR4KDRFGFR1RETPDGFRB
Lenvatinib SCHEMBL864638 0.89 FGFR4 (1.00) FGFR4KDRFGFR1RETPDGFRB
Lenvatinib SCHEMBL29372021 0.89 FGFR4 (1.00) FGFR4KDRFGFR1RETPDGFRB
SCHEMBL12412057 0.89 FGFR4 (0.76) FGFR4KDRFGFR1RETPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110293615-A1 Use of Combination of Anti-Angiogenic Substance and c-kit Kinase Inhibitor EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-12-01 US claimed
EP-2281901-A2 Anti-tumour pharmaceutical composition with angiogenesis inhibitors Eisai R&D Management Co., Ltd. (JP) 2011-02-09 EP claimed
EP-2248804-A1 COMBINED USE OF ANGIOGENESIS INHIBITOR AND TAXANE Eisai R&D Management Co., Ltd. (JP) 2010-11-10 EP claimed
US-20100239688-A1 COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND ANTI-TUMOR PLATINUM COMPLEX EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-09-23 US claimed
EP-2218712-A1 COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND ANTI-TUMOR PLATINUM COMPLEX Eisai R&D Management Co., Ltd. (JP) 2010-08-18 EP claimed
US-20100105031-A1 METHOD FOR PREDICTION OF THE EFFICACY OF VASCULARIZATION INHIBITOR ESAI R & D MANAGEMENT CO., LTD. (JP) 2010-04-29 US claimed
US-20100092490-A1 METHOD FOR ASSAY ON THE EFFECT OF VASCULARIZATION INHIBITOR EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-04-15 US claimed
EP-2116246-A1 COMPOSITION FOR TREATMENT OF PANCREATIC CANCER Eisai R&D Management Co., Ltd. (JP) 2009-11-11 EP claimed
US-20090264464-A1 ANTITUMOR AGENT FOR UNDIFFERENTIATED GASTRIC CANCER EISAI R & D MANAGEMENT CO., LTD. (JP) 2009-10-22 US claimed
US-20090247576-A1 ANTI-TUMOR AGENT FOR MULTIPLE MYELOMA EISAI R & D MANAGEMENT CO., LTD. (JP) 2009-10-01 US claimed
EP-2065372-A1 ANTITUMOR AGENT FOR UNDIFFERENTIATED GASTRIC CANCER Eisai R&D Management Co., Ltd. (JP) 2009-06-03 EP claimed
EP-2044939-A1 THERAPEUTIC AGENT FOR LIVER FIBROSIS Eisai R&D Management Co., Ltd. (JP) 2009-04-08 EP claimed
EP-2036557-A1 ANTITUMOR AGENT FOR THYROID CANCER Eisai R&D Management Co., Ltd. (JP) 2009-03-18 EP claimed
US-20090053236-A1 USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR EISAI R & D MANAGEMENT CO., LTD. (JP) 2009-02-26 US claimed
EP-1964837-A1 ANTI-TUMOR AGENT FOR MULTIPLE MYELOMA Eisai R&D Management Co., Ltd. (JP) 2008-09-03 EP claimed
EP-1949902-A1 USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR Eisai R&D Management Co., Ltd. (JP) 2008-07-30 EP claimed
EP-1925676-A1 METHOD FOR ASSAY ON THE EFFECT OF VASCULARIZATION INHIBITOR Eisai R&D Management Co., Ltd. (JP) 2008-05-28 EP claimed
EP-1925941-A1 METHOD FOR PREDICTION OF THE EFFICACY OF VASCULARIZATION INHIBITOR Eisai R&D Management Co., Ltd. (JP) 2008-05-28 EP claimed
EP-1797877-A1 JOINT USE OF SULFONAMIDE BASED COMPOUND WITH ANGIOGENESIS INHIBITOR Eisai Co., Ltd. (JP) 2007-06-20 EP claimed
US-20060135486-A1 Use of sulfonamide-including compounds in combination with angiogenesis inhibitors EISAI CO., LTD. (JP) 2006-06-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239688-A1 COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND ANTI-TUMOR PLATINUM COMPLEX PGF, VEGFA, FLT4 FGFR4 389/4885KDR 16/4885FGFR1 1011/4885
US-20090247576-A1 ANTI-TUMOR AGENT FOR MULTIPLE MYELOMA FGFR3, MCTS1, TP53 FGFR4 5/4885KDR 2806/4885FGFR1 12/4885
US-20060135486-A1 Use of sulfonamide-including compounds in combination with angiogenesis inhibitors FLT4, KDR, FLT1 FGFR4 49/4885KDR 2/4885FGFR1 30/4885
US-20100092490-A1 METHOD FOR ASSAY ON THE EFFECT OF VASCULARIZATION INHIBITOR VEGFA, FLT4, MKI67 FGFR4 70/4885KDR 6/4885FGFR1 87/4885
US-20110293615-A1 Use of Combination of Anti-Angiogenic Substance and c-kit Kinase Inhibitor KIT, FLT4, KDR FGFR4 476/4885KDR 3/4885FGFR1 393/4885
US-20090264464-A1 ANTITUMOR AGENT FOR UNDIFFERENTIATED GASTRIC CANCER FGFR2, FGFR3, FGF2 FGFR4 6/4885KDR 340/4885FGFR1 4/4885
US-20090053236-A1 USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR KIT, FLT4, KDR FGFR4 476/4885KDR 3/4885FGFR1 393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.