Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.81 |
| ▸ | HTR6 | P50406 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 9/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599893 | 0.90 | KCNH2 (0.74) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL2739092 | 0.90 | KCNH2 (1.00) | KCNH2HTR6DRD2HTR1BHTR2C | |
| Hydrochloric Acid SCHEMBL27817823 | 0.89 | KCNH2 (0.98) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL8642973 | 0.89 | KCNH2 (0.73) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL6967113 | 0.88 | KCNH2 (0.71) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL6579238 | 0.84 | KCNH2 (0.66) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL6579260 | 0.82 | KCNH2 (0.64) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL6581472 | 0.82 | KCNH2 (0.64) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL9150576 | 0.82 | KCNH2 (0.82) | KCNH2HTR6DRD2HTR1BHTR2C | |
| SCHEMBL9146788 | 0.82 | KCNH2 (0.64) | KCNH2HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| US-5439922-A | Administering dopamine antagonists having reduced side effects | H. LUNDBECK A/S (DK) | 1995-08-08 | — | — | US | disclosed |
| EP-0533824-B1 | PIPERIDYL-SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 1994-11-09 | — | — | EP | disclosed |