Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 9/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579260 | 0.86 | KCNH2 (0.64) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL8640342 | 0.82 | KCNH2 (0.81) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL6583096 | 0.82 | HTR1A (0.72) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL6579238 | 0.79 | KCNH2 (0.66) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL2739092 | 0.78 | KCNH2 (1.00) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL6599893 | 0.78 | KCNH2 (0.74) | KCNH2DRD2HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL27817823 | 0.77 | KCNH2 (0.98) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL8642973 | 0.77 | KCNH2 (0.73) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL6967113 | 0.76 | KCNH2 (0.71) | KCNH2DRD2HTR6HTR2AHTR2C | |
| SCHEMBL6583347 | 0.75 | HTR6 (0.52) | KCNH2HTR6HTR1ADRD3SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833376-B2 | 5-aminoalkyl and 5-aminocarbonyl substituted indole derivative useful for treatment of psychosis in a mammal | H. LUNDBECK A/S (DK) | 2004-12-21 | — | — | US | disclosed |
| EP-1214312-B1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2004-04-14 | — | — | EP | disclosed |
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | H. LUNDBECK A/S (DK) | 2002-11-14 | — | — | US | disclosed |
| EP-1214312-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001021614-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | ADRB1, ADRA2C, ADRB2 | KCNH2 79/4885DRD2 188/4885HTR6 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.